---
page_type: error
code: 21216
message: "21216: API: Call blocked by Twilio"
level: ERROR
product: Programmable Voice
---

## Description

The destination number is blocked by Twilio.

### Possible Causes

The outbound call to the destination number was blocked by Twilio. Potential causes may be:

- The destination has a high-risk of fraud
- Due to regulatory reasons, the destination cannot be reached
- You are placing a call to a +1 destination and your account is missing a Primary Customer Profile

### Possible Solutions

Potential solutions may be:

- If your destination is being incorrectly identified as high-risk of fraud and you have a legitimate need to call this number, please reach out to Twilio Support through the [Console](https://console.twilio.com) or [Help Center](https://support.twilio.com/hc/en-us).
- If you are placing a call to a +1 destination and your account is missing a Primary Customer Profile, create one in [TrustHub](https://console.twilio.com/us1/account/trust-hub/customer-profiles).